Genetic Dissection of Rod and Cone Pathways in the Dark-Adapted Mouse Retina

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Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.

A monumental task of the mammalian retina is to encode an enormous range (>10(9)-fold) of light intensities experienced by the animal in natural environments. Retinal neurons carry out this task by dividing labor into many parallel rod and cone synaptic pathways. Here we study the operational plan of various rod- and cone-mediated pathways by analyzing electroretinograms (ERGs), primarily b-wav...

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Genetic Dissection of Rod and Cone Pathways

45 A monumental task of the mammalian retina is to encode an enormous range (> 10 fold) 46 of light intensities experienced by the animal in the natural environment. Retinal neurons 47 carry out this task by dividing labor into many parallel rod and cone synaptic pathways. 48 Here we study the operational plan of various rod and cone mediated pathways by 49 analyzing electroretinograms (ERGs), ...

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Microcircuitry of the dark-adapted cat retina: functional architecture of the rod-cone network.

The structure of the rod-cone network in the area centralis of cat retina was studied by reconstruction from serial electron micrographs. About 48 rods converge on each cone via gap junctions between the rod spherules and the basal processes of the cone pedicle. One rod diverges to 2.4 cones through these gap junctions, and each cone connects to 8 other cones, also through gap junctions. A stat...

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PURPOSE The rodent retina does not exhibit a positive OFF-response in the electroretinogram (ERG), which makes it difficult to evaluate its OFF-pathway functions in vivo. We studied the rod-driven OFF pathway responses by using a dark-adapted 10-Hz flicker ERG procedure in mouse. MATERIALS AND METHODS Conventional ERGs and 10-Hz dark-adapted flicker ERGs were obtained in wild-type mice (C57BL...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2009

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00142.2009